diff --git a/configure b/configure
index 0e6dea4758d..12783b339b6 100755
--- a/configure
+++ b/configure
@@ -14421,32 +14421,6 @@ $as_echo "$ac_cv_cpp_def___x86_64__" >&6; }
 if test $ac_cv_cpp_def___x86_64__ = yes; then :
   CFLAGS="$CFLAGS -D__x86_64__"
   LINTFLAGS="$LINTFLAGS -D__x86_64__"
-fi ;;
-  *alpha*)          { $as_echo "$as_me:${as_lineno-$LINENO}: checking whether we need to define __ALPHA__" >&5
-$as_echo_n "checking whether we need to define __ALPHA__... " >&6; }
-if test "${ac_cv_cpp_def___ALPHA__+set}" = set; then :
-  $as_echo_n "(cached) " >&6
-else
-  cat confdefs.h - <<_ACEOF >conftest.$ac_ext
-/* end confdefs.h.  */
-#ifndef __ALPHA__
-yes
-#endif
-_ACEOF
-if (eval "$ac_cpp conftest.$ac_ext") 2>&5 |
-  $EGREP "yes" >/dev/null 2>&1; then :
-  ac_cv_cpp_def___ALPHA__=yes
-else
-  ac_cv_cpp_def___ALPHA__=no
-fi
-rm -f conftest*
-
-fi
-{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_cpp_def___ALPHA__" >&5
-$as_echo "$ac_cv_cpp_def___ALPHA__" >&6; }
-if test $ac_cv_cpp_def___ALPHA__ = yes; then :
-  CFLAGS="$CFLAGS -D__ALPHA__"
-  LINTFLAGS="$LINTFLAGS -D__ALPHA__"
 fi ;;
   *sparc*)          { $as_echo "$as_me:${as_lineno-$LINENO}: checking whether we need to define __sparc__" >&5
 $as_echo_n "checking whether we need to define __sparc__... " >&6; }
diff --git a/configure.ac b/configure.ac
index 60477443bd8..2b92883976d 100644
--- a/configure.ac
+++ b/configure.ac
@@ -2332,7 +2332,6 @@ dnl *** check for the need to define platform-specific symbols
 case $host_cpu in
   *i[[3456789]]86*) WINE_CHECK_DEFINE([__i386__]) ;;
   *x86_64*)         WINE_CHECK_DEFINE([__x86_64__]) ;;
-  *alpha*)          WINE_CHECK_DEFINE([__ALPHA__]) ;;
   *sparc*)          WINE_CHECK_DEFINE([__sparc__]) ;;
   *powerpc*)        WINE_CHECK_DEFINE([__powerpc__]) ;;
 esac