diff --git a/dlls/comctl32/tests/rebar.c b/dlls/comctl32/tests/rebar.c
index 6c82295d40b..21b655b197f 100644
--- a/dlls/comctl32/tests/rebar.c
+++ b/dlls/comctl32/tests/rebar.c
@@ -17,10 +17,6 @@
  * Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301, USA
  */
 
-/* make sure the structures work with a comctl32 v5.x */
-#define _WIN32_WINNT 0x500
-#define _WIN32_IE 0x500
-
 #include <assert.h>
 #include <stdarg.h>
 
diff --git a/dlls/riched20/editstr.h b/dlls/riched20/editstr.h
index a2e6f8584b7..608901a5e22 100644
--- a/dlls/riched20/editstr.h
+++ b/dlls/riched20/editstr.h
@@ -21,10 +21,6 @@
 #ifndef __EDITSTR_H
 #define __EDITSTR_H
 
-#ifndef _WIN32_IE
-#define _WIN32_IE 0x0400
-#endif
-
 #include <assert.h>
 #include <stdarg.h>
 #include <stdio.h>
diff --git a/dlls/shell32/tests/systray.c b/dlls/shell32/tests/systray.c
index 0d815a6011e..ba5832e51c7 100644
--- a/dlls/shell32/tests/systray.c
+++ b/dlls/shell32/tests/systray.c
@@ -16,7 +16,7 @@
  * License along with this library; if not, write to the Free Software
  * Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301, USA
  */
-#define _WIN32_IE 0x600
+
 #include <stdarg.h>
 
 #include <windows.h>
diff --git a/dlls/urlmon/tests/sec_mgr.c b/dlls/urlmon/tests/sec_mgr.c
index 0577af4ecc9..4d61079ab83 100644
--- a/dlls/urlmon/tests/sec_mgr.c
+++ b/dlls/urlmon/tests/sec_mgr.c
@@ -21,9 +21,6 @@
 #define COBJMACROS
 #define CONST_VTABLE
 
-/* needed for IInternetZoneManagerEx2 */
-#define _WIN32_IE 0x0700
-
 #include <wine/test.h>
 #include <stdarg.h>
 #include <stddef.h>
diff --git a/dlls/user32/tests/input.c b/dlls/user32/tests/input.c
index ddaf7541e48..3fc84f61083 100644
--- a/dlls/user32/tests/input.c
+++ b/dlls/user32/tests/input.c
@@ -45,9 +45,6 @@
  *
  */
 
-#define _WIN32_WINNT 0x401
-#define _WIN32_IE 0x0500
-
 #include <stdarg.h>
 #include <assert.h>
 
diff --git a/include/commctrl.h b/include/commctrl.h
index b503f9ef24b..dfd2f4a37d2 100644
--- a/include/commctrl.h
+++ b/include/commctrl.h
@@ -53,10 +53,6 @@ HRESULT WINAPI LoadIconMetric(HINSTANCE, const WCHAR *, int, HICON *);
 
 #define COMCTL32_VERSION                5  /* dll version */
 
-#ifndef _WIN32_IE
-#define _WIN32_IE 0x0400
-#endif
-
 #define ICC_LISTVIEW_CLASSES   0x00000001  /* listview, header */
 #define ICC_TREEVIEW_CLASSES   0x00000002  /* treeview, tooltips */
 #define ICC_BAR_CLASSES        0x00000004  /* toolbar, statusbar, trackbar, tooltips */
diff --git a/programs/explorer/systray.c b/programs/explorer/systray.c
index f9e6661af4f..dcd75f4e763 100644
--- a/programs/explorer/systray.c
+++ b/programs/explorer/systray.c
@@ -21,7 +21,6 @@
 #include <assert.h>
 
 #define NONAMELESSUNION
-#define _WIN32_IE 0x500
 #include <windows.h>
 #include <commctrl.h>
 #include <shellapi.h>
diff --git a/programs/wordpad/wordpad.c b/programs/wordpad/wordpad.c
index 579291be804..c8e3132b343 100644
--- a/programs/wordpad/wordpad.c
+++ b/programs/wordpad/wordpad.c
@@ -20,7 +20,6 @@
  */
 
 #define WIN32_LEAN_AND_MEAN
-#define _WIN32_IE 0x0400
 
 #include <stdarg.h>
 #include <stdlib.h>