diff --git a/dlls/wow64/Makefile.in b/dlls/wow64/Makefile.in
index 76e3ff97d6b..4ab1b088dff 100644
--- a/dlls/wow64/Makefile.in
+++ b/dlls/wow64/Makefile.in
@@ -5,5 +5,6 @@ IMPORTS   = ntdll winecrt0
 EXTRADLLFLAGS = -nodefaultlibs -mno-cygwin -Wl,--image-base,0x6f000000
 
 C_SRCS = \
+	registry.c \
 	sync.c \
 	syscall.c
diff --git a/dlls/wow64/registry.c b/dlls/wow64/registry.c
new file mode 100644
index 00000000000..435c7669c28
--- /dev/null
+++ b/dlls/wow64/registry.c
@@ -0,0 +1,251 @@
+/*
+ * WoW64 registry functions
+ *
+ * Copyright 2021 Alexandre Julliard
+ *
+ * This library is free software; you can redistribute it and/or
+ * modify it under the terms of the GNU Lesser General Public
+ * License as published by the Free Software Foundation; either
+ * version 2.1 of the License, or (at your option) any later version.
+ *
+ * This library is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
+ * Lesser General Public License for more details.
+ *
+ * You should have received a copy of the GNU Lesser General Public
+ * License along with this library; if not, write to the Free Software
+ * Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301, USA
+ */
+
+#include <stdarg.h>
+
+#include "ntstatus.h"
+#define WIN32_NO_STATUS
+#include "windef.h"
+#include "winbase.h"
+#include "winnt.h"
+#include "winternl.h"
+#include "wow64_private.h"
+
+
+/**********************************************************************
+ *           wow64_NtCreateKey
+ */
+NTSTATUS WINAPI wow64_NtCreateKey( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    ULONG index = get_ulong( &args );
+    UNICODE_STRING32 *class32 = get_ptr( &args );
+    ULONG options = get_ulong( &args );
+    ULONG *dispos = get_ptr( &args );
+
+    struct object_attr64 attr;
+    UNICODE_STRING class;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtCreateKey( &handle, access, objattr_32to64( &attr, attr32 ), index,
+                          unicode_str_32to64( &class, class32 ), options, dispos );
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtCreateKeyTransacted
+ */
+NTSTATUS WINAPI wow64_NtCreateKeyTransacted( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    ULONG index = get_ulong( &args );
+    UNICODE_STRING32 *class32 = get_ptr( &args );
+    ULONG options = get_ulong( &args );
+    HANDLE transacted = get_handle( &args );
+    ULONG *dispos = get_ptr( &args );
+
+    struct object_attr64 attr;
+    UNICODE_STRING class;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtCreateKeyTransacted( &handle, access, objattr_32to64( &attr, attr32 ), index,
+                                    unicode_str_32to64( &class, class32 ), options, transacted, dispos );
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtDeleteKey
+ */
+NTSTATUS WINAPI wow64_NtDeleteKey( UINT *args )
+{
+    HANDLE handle = get_handle( &args );
+
+    return NtDeleteKey( handle );
+}
+
+
+/**********************************************************************
+ *           wow64_NtEnumerateKey
+ */
+NTSTATUS WINAPI wow64_NtEnumerateKey( UINT *args )
+{
+    HANDLE handle = get_handle( &args );
+    ULONG index = get_ulong( &args );
+    KEY_INFORMATION_CLASS class = get_ulong( &args );
+    void *ptr = get_ptr( &args );
+    ULONG len = get_ulong( &args );
+    ULONG *retlen = get_ptr( &args );
+
+    return NtEnumerateKey( handle, index, class, ptr, len, retlen );
+}
+
+
+/**********************************************************************
+ *           wow64_NtOpenKey
+ */
+NTSTATUS WINAPI wow64_NtOpenKey( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+
+    struct object_attr64 attr;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtOpenKey( &handle, access, objattr_32to64( &attr, attr32 ));
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtOpenKeyEx
+ */
+NTSTATUS WINAPI wow64_NtOpenKeyEx( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    ULONG options = get_ulong( &args );
+
+    struct object_attr64 attr;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtOpenKeyEx( &handle, access, objattr_32to64( &attr, attr32 ), options );
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtOpenKeyTransacted
+ */
+NTSTATUS WINAPI wow64_NtOpenKeyTransacted( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    HANDLE transaction = get_handle( &args );
+
+    struct object_attr64 attr;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtOpenKeyTransacted( &handle, access, objattr_32to64( &attr, attr32 ), transaction );
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtOpenKeyTransactedEx
+ */
+NTSTATUS WINAPI wow64_NtOpenKeyTransactedEx( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    ULONG options = get_ulong( &args );
+    HANDLE transaction = get_handle( &args );
+
+    struct object_attr64 attr;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtOpenKeyTransactedEx( &handle, access, objattr_32to64( &attr, attr32 ), options, transaction );
+    put_handle( handle_ptr, handle );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtQueryKey
+ */
+NTSTATUS WINAPI wow64_NtQueryKey( UINT *args )
+{
+    HANDLE handle = get_handle( &args );
+    KEY_INFORMATION_CLASS class = get_ulong( &args );
+    void *info = get_ptr( &args );
+    ULONG len = get_ulong( &args );
+    ULONG *retlen = get_ptr( &args );
+
+    return NtQueryKey( handle, class, info, len, retlen );
+}
+
+
+/**********************************************************************
+ *           wow64_NtRenameKey
+ */
+NTSTATUS WINAPI wow64_NtRenameKey( UINT *args )
+{
+    HANDLE handle = get_handle( &args );
+    UNICODE_STRING32 *str32 = get_ptr( &args );
+
+    UNICODE_STRING str;
+
+    return NtRenameKey( handle, unicode_str_32to64( &str, str32 ));
+}
+
+
+/**********************************************************************
+ *           wow64_NtReplaceKey
+ */
+NTSTATUS WINAPI wow64_NtReplaceKey( UINT *args )
+{
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    HANDLE handle = get_handle( &args );
+    OBJECT_ATTRIBUTES32 *replace32 = get_ptr( &args );
+
+    struct object_attr64 attr, replace;
+
+    return NtReplaceKey( objattr_32to64( &attr, attr32 ), handle, objattr_32to64( &replace, replace32 ));
+}
+
+
+/**********************************************************************
+ *           wow64_NtSetInformationKey
+ */
+NTSTATUS WINAPI wow64_NtSetInformationKey( UINT *args )
+{
+    HANDLE handle = get_handle( &args );
+    int class = get_ulong( &args );
+    void *info = get_ptr( &args );
+    ULONG len = get_ulong( &args );
+
+    return NtSetInformationKey( handle, class, info, len );
+}
diff --git a/dlls/wow64/syscall.h b/dlls/wow64/syscall.h
index e7b0353a90a..cf579576839 100644
--- a/dlls/wow64/syscall.h
+++ b/dlls/wow64/syscall.h
@@ -37,6 +37,8 @@
     SYSCALL_ENTRY( NtCreateEvent ) \
     SYSCALL_ENTRY( NtCreateIoCompletion ) \
     SYSCALL_ENTRY( NtCreateJobObject ) \
+    SYSCALL_ENTRY( NtCreateKey ) \
+    SYSCALL_ENTRY( NtCreateKeyTransacted ) \
     SYSCALL_ENTRY( NtCreateKeyedEvent ) \
     SYSCALL_ENTRY( NtCreateMutant ) \
     SYSCALL_ENTRY( NtCreatePort ) \
@@ -48,7 +50,9 @@
     SYSCALL_ENTRY( NtDebugContinue ) \
     SYSCALL_ENTRY( NtDelayExecution ) \
     SYSCALL_ENTRY( NtDeleteAtom ) \
+    SYSCALL_ENTRY( NtDeleteKey ) \
     SYSCALL_ENTRY( NtDuplicateObject ) \
+    SYSCALL_ENTRY( NtEnumerateKey ) \
     SYSCALL_ENTRY( NtFindAtom ) \
     SYSCALL_ENTRY( NtGetCurrentProcessorNumber ) \
     SYSCALL_ENTRY( NtListenPort ) \
@@ -57,6 +61,10 @@
     SYSCALL_ENTRY( NtOpenEvent ) \
     SYSCALL_ENTRY( NtOpenIoCompletion ) \
     SYSCALL_ENTRY( NtOpenJobObject ) \
+    SYSCALL_ENTRY( NtOpenKey ) \
+    SYSCALL_ENTRY( NtOpenKeyEx ) \
+    SYSCALL_ENTRY( NtOpenKeyTransacted ) \
+    SYSCALL_ENTRY( NtOpenKeyTransactedEx ) \
     SYSCALL_ENTRY( NtOpenKeyedEvent ) \
     SYSCALL_ENTRY( NtOpenMutant ) \
     SYSCALL_ENTRY( NtOpenSection ) \
@@ -71,6 +79,7 @@
     SYSCALL_ENTRY( NtQueryInformationAtom ) \
     SYSCALL_ENTRY( NtQueryInstallUILanguage ) \
     SYSCALL_ENTRY( NtQueryIoCompletion ) \
+    SYSCALL_ENTRY( NtQueryKey ) \
     SYSCALL_ENTRY( NtQueryMutant ) \
     SYSCALL_ENTRY( NtQueryObject ) \
     SYSCALL_ENTRY( NtQueryPerformanceCounter ) \
@@ -82,6 +91,8 @@
     SYSCALL_ENTRY( NtReleaseKeyedEvent ) \
     SYSCALL_ENTRY( NtReleaseMutant ) \
     SYSCALL_ENTRY( NtReleaseSemaphore ) \
+    SYSCALL_ENTRY( NtRenameKey ) \
+    SYSCALL_ENTRY( NtReplaceKey ) \
     SYSCALL_ENTRY( NtReplyWaitReceivePort ) \
     SYSCALL_ENTRY( NtRequestWaitReplyPort ) \
     SYSCALL_ENTRY( NtResetEvent ) \
@@ -90,6 +101,7 @@
     SYSCALL_ENTRY( NtSetDefaultUILanguage ) \
     SYSCALL_ENTRY( NtSetEvent ) \
     SYSCALL_ENTRY( NtSetInformationDebugObject ) \
+    SYSCALL_ENTRY( NtSetInformationKey ) \
     SYSCALL_ENTRY( NtSetInformationObject ) \
     SYSCALL_ENTRY( NtSetIoCompletion ) \
     SYSCALL_ENTRY( NtSetPowerRequest ) \