diff --git a/configure b/configure
index 87cd2906e6e..5c01f4a27cb 100755
--- a/configure
+++ b/configure
@@ -682,6 +682,8 @@ GPHOTO2_PORT_LIBS
 GPHOTO2_PORT_CFLAGS
 GPHOTO2_LIBS
 GPHOTO2_CFLAGS
+USB_LIBS
+USB_CFLAGS
 SANE_LIBS
 SANE_CFLAGS
 GNUTLS_LIBS
@@ -880,6 +882,7 @@ with_sdl
 with_tiff
 with_udev
 with_unwind
+with_usb
 with_v4l2
 with_vkd3d
 with_vulkan
@@ -1645,6 +1648,7 @@ enable_wineoss_drv
 enable_wineps_drv
 enable_winepulse_drv
 enable_wineqtdecoder
+enable_wineusb_sys
 enable_winevulkan
 enable_winex11_drv
 enable_wing32
@@ -1857,6 +1861,8 @@ GNUTLS_CFLAGS
 GNUTLS_LIBS
 SANE_CFLAGS
 SANE_LIBS
+USB_CFLAGS
+USB_LIBS
 GPHOTO2_CFLAGS
 GPHOTO2_LIBS
 GPHOTO2_PORT_CFLAGS
@@ -2583,6 +2589,7 @@ Optional Packages:
   --without-udev          do not use udev (plug and play support)
   --without-unwind        do not use the libunwind library (exception
                           handling)
+  --without-usb           do not use the libusb library
   --without-v4l2          do not use v4l2 (video capture)
   --without-vkd3d         do not use vkd3d (Direct3D 12 support)
   --without-vulkan        do not use Vulkan
@@ -2635,6 +2642,8 @@ Some influential environment variables:
   GNUTLS_LIBS Linker flags for gnutls, overriding pkg-config
   SANE_CFLAGS C compiler flags for libsane, overriding pkg-config
   SANE_LIBS   Linker flags for libsane, overriding pkg-config
+  USB_CFLAGS  C compiler flags for libusb-1.0, overriding pkg-config
+  USB_LIBS    Linker flags for libusb-1.0, overriding pkg-config
   GPHOTO2_CFLAGS
               C compiler flags for libgphoto2, overriding pkg-config
   GPHOTO2_LIBS
@@ -4110,6 +4119,12 @@ if test "${with_unwind+set}" = set; then :
 fi
 
 
+# Check whether --with-usb was given.
+if test "${with_usb+set}" = set; then :
+  withval=$with_usb;
+fi
+
+
 # Check whether --with-v4l2 was given.
 if test "${with_v4l2+set}" = set; then :
   withval=$with_v4l2;
@@ -13905,6 +13920,89 @@ esac
 
 fi
 
+if test "x$with_usb" != "xno"
+then
+    if ${USB_CFLAGS:+false} :; then :
+  if ${PKG_CONFIG+:} false; then :
+  USB_CFLAGS=`$PKG_CONFIG --cflags libusb-1.0 2>/dev/null`
+fi
+fi
+
+if ${USB_LIBS:+false} :; then :
+  if ${PKG_CONFIG+:} false; then :
+  USB_LIBS=`$PKG_CONFIG --libs libusb-1.0 2>/dev/null`
+fi
+fi
+
+USB_LIBS=${USB_LIBS:-"-lusb-1.0"}
+$as_echo "$as_me:${as_lineno-$LINENO}: libusb-1.0 cflags: $USB_CFLAGS" >&5
+$as_echo "$as_me:${as_lineno-$LINENO}: libusb-1.0 libs: $USB_LIBS" >&5
+ac_save_CPPFLAGS=$CPPFLAGS
+CPPFLAGS="$CPPFLAGS $USB_CFLAGS"
+ac_fn_c_check_header_mongrel "$LINENO" "libusb.h" "ac_cv_header_libusb_h" "$ac_includes_default"
+if test "x$ac_cv_header_libusb_h" = xyes; then :
+  { $as_echo "$as_me:${as_lineno-$LINENO}: checking for libusb_init in -lusb-1.0" >&5
+$as_echo_n "checking for libusb_init in -lusb-1.0... " >&6; }
+if ${ac_cv_lib_usb_1_0_libusb_init+:} false; then :
+  $as_echo_n "(cached) " >&6
+else
+  ac_check_lib_save_LIBS=$LIBS
+LIBS="-lusb-1.0 $USB_LIBS $LIBS"
+cat confdefs.h - <<_ACEOF >conftest.$ac_ext
+/* end confdefs.h.  */
+
+/* Override any GCC internal prototype to avoid an error.
+   Use char because int might match the return type of a GCC
+   builtin and then its argument prototype would still apply.  */
+#ifdef __cplusplus
+extern "C"
+#endif
+char libusb_init ();
+int
+main ()
+{
+return libusb_init ();
+  ;
+  return 0;
+}
+_ACEOF
+if ac_fn_c_try_link "$LINENO"; then :
+  ac_cv_lib_usb_1_0_libusb_init=yes
+else
+  ac_cv_lib_usb_1_0_libusb_init=no
+fi
+rm -f core conftest.err conftest.$ac_objext \
+    conftest$ac_exeext conftest.$ac_ext
+LIBS=$ac_check_lib_save_LIBS
+fi
+{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_lib_usb_1_0_libusb_init" >&5
+$as_echo "$ac_cv_lib_usb_1_0_libusb_init" >&6; }
+if test "x$ac_cv_lib_usb_1_0_libusb_init" = xyes; then :
+  :
+else
+  USB_LIBS=""
+fi
+
+else
+  USB_LIBS=""
+fi
+
+
+CPPFLAGS=$ac_save_CPPFLAGS
+test -z "$USB_CFLAGS" || USB_CFLAGS=`echo " $USB_CFLAGS" | sed 's/ -I\([^/]\)/ -I\$(top_builddir)\/\1/g'`
+test -z "$USB_LIBS" || USB_LIBS=`echo " $USB_LIBS" | sed 's/ -L\([^/]\)/ -L\$(top_builddir)\/\1/g'`
+
+fi
+if test "$ac_cv_lib_usb_1_0_libusb_init" != "yes"; then :
+  case "x$with_usb" in
+  x)   as_fn_append wine_notices "|libusb-1.0 ${notice_platform}development files not found, USB devices won't be supported." ;;
+  xno) ;;
+  *)   as_fn_error $? "libusb-1.0 ${notice_platform}development files not found, USB devices won't be supported.
+This is an error since --with-usb was requested." "$LINENO" 5 ;;
+esac
+enable_wineusb_sys=${enable_wineusb_sys:-no}
+fi
+
 if test "x$with_v4l2" != "xno"
 then
     { $as_echo "$as_me:${as_lineno-$LINENO}: checking for -lv4l2" >&5
@@ -19925,6 +20023,8 @@ GNUTLS_CFLAGS = $GNUTLS_CFLAGS
 GNUTLS_LIBS = $GNUTLS_LIBS
 SANE_CFLAGS = $SANE_CFLAGS
 SANE_LIBS = $SANE_LIBS
+USB_CFLAGS = $USB_CFLAGS
+USB_LIBS = $USB_LIBS
 GPHOTO2_CFLAGS = $GPHOTO2_CFLAGS
 GPHOTO2_LIBS = $GPHOTO2_LIBS
 GPHOTO2_PORT_CFLAGS = $GPHOTO2_PORT_CFLAGS
@@ -21003,6 +21103,7 @@ wine_fn_config_makefile dlls/wineps.drv enable_wineps_drv
 wine_fn_config_makefile dlls/wineps16.drv16 enable_win16
 wine_fn_config_makefile dlls/winepulse.drv enable_winepulse_drv
 wine_fn_config_makefile dlls/wineqtdecoder enable_wineqtdecoder
+wine_fn_config_makefile dlls/wineusb.sys enable_wineusb_sys
 wine_fn_config_makefile dlls/winevulkan enable_winevulkan
 wine_fn_config_makefile dlls/winex11.drv enable_winex11_drv
 wine_fn_config_makefile dlls/wing.dll16 enable_win16
diff --git a/configure.ac b/configure.ac
index d5c67e38790..2a472864b1d 100644
--- a/configure.ac
+++ b/configure.ac
@@ -84,6 +84,7 @@ AC_ARG_WITH(sdl,       AS_HELP_STRING([--without-sdl],[do not use SDL]))
 AC_ARG_WITH(tiff,      AS_HELP_STRING([--without-tiff],[do not use TIFF]))
 AC_ARG_WITH(udev,      AS_HELP_STRING([--without-udev],[do not use udev (plug and play support)]))
 AC_ARG_WITH(unwind,    AS_HELP_STRING([--without-unwind],[do not use the libunwind library (exception handling)]))
+AC_ARG_WITH(usb,       AS_HELP_STRING([--without-usb],[do not use the libusb library]))
 AC_ARG_WITH(v4l2,      AS_HELP_STRING([--without-v4l2],[do not use v4l2 (video capture)]))
 AC_ARG_WITH(vkd3d,     AS_HELP_STRING([--without-vkd3d],[do not use vkd3d (Direct3D 12 support)]))
 AC_ARG_WITH(vulkan,    AS_HELP_STRING([--without-vulkan],[do not use Vulkan]))
@@ -1474,6 +1475,18 @@ fi
 WINE_NOTICE_WITH(sane,[test "x$ac_cv_lib_soname_sane" = "x"],
                  [libsane ${notice_platform}development files not found, scanners won't be supported.])
 
+dnl **** Check for libusb ****
+if test "x$with_usb" != "xno"
+then
+    WINE_PACKAGE_FLAGS(USB,[libusb-1.0],[-lusb-1.0],,,
+        [AC_CHECK_HEADER([libusb.h],
+            [AC_CHECK_LIB(usb-1.0,libusb_init,[:],[USB_LIBS=""],[$USB_LIBS])],
+            [USB_LIBS=""])])
+fi
+WINE_NOTICE_WITH(usb,[test "$ac_cv_lib_usb_1_0_libusb_init" != "yes"],
+                 [libusb-1.0 ${notice_platform}development files not found, USB devices won't be supported.],
+                 [enable_wineusb_sys])
+
 dnl **** Check for libv4l2 ****
 if test "x$with_v4l2" != "xno"
 then
@@ -3780,6 +3793,7 @@ WINE_CONFIG_MAKEFILE(dlls/wineps.drv)
 WINE_CONFIG_MAKEFILE(dlls/wineps16.drv16,enable_win16)
 WINE_CONFIG_MAKEFILE(dlls/winepulse.drv)
 WINE_CONFIG_MAKEFILE(dlls/wineqtdecoder)
+WINE_CONFIG_MAKEFILE(dlls/wineusb.sys)
 WINE_CONFIG_MAKEFILE(dlls/winevulkan)
 WINE_CONFIG_MAKEFILE(dlls/winex11.drv)
 WINE_CONFIG_MAKEFILE(dlls/wing.dll16,enable_win16)
diff --git a/dlls/wineusb.sys/Makefile.in b/dlls/wineusb.sys/Makefile.in
new file mode 100644
index 00000000000..bac79f668e8
--- /dev/null
+++ b/dlls/wineusb.sys/Makefile.in
@@ -0,0 +1,8 @@
+MODULE    = wineusb.sys
+IMPORTS   = ntoskrnl
+EXTRALIBS = $(USB_LIBS)
+EXTRAINCL = $(USB_CFLAGS)
+EXTRADLLFLAGS = -Wl,--subsystem,native
+
+C_SRCS = \
+	wineusb.c
diff --git a/dlls/wineusb.sys/wineusb.c b/dlls/wineusb.sys/wineusb.c
new file mode 100644
index 00000000000..b26f1036d82
--- /dev/null
+++ b/dlls/wineusb.sys/wineusb.c
@@ -0,0 +1,61 @@
+/*
+ * USB root device enumerator using libusb
+ *
+ * Copyright 2020 Zebediah Figura
+ *
+ * This library is free software; you can redistribute it and/or
+ * modify it under the terms of the GNU Lesser General Public
+ * License as published by the Free Software Foundation; either
+ * version 2.1 of the License, or (at your option) any later version.
+ *
+ * This library is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
+ * Lesser General Public License for more details.
+ *
+ * You should have received a copy of the GNU Lesser General Public
+ * License along with this library; if not, write to the Free Software
+ * Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301, USA
+ */
+
+#include <assert.h>
+#include <stdarg.h>
+#include <stdlib.h>
+#include <libusb.h>
+
+#include "ntstatus.h"
+#define WIN32_NO_STATUS
+#include "windef.h"
+#include "winioctl.h"
+#include "winternl.h"
+#include "ddk/wdm.h"
+#include "ddk/usb.h"
+#include "ddk/usbioctl.h"
+#include "wine/asm.h"
+#include "wine/debug.h"
+#include "wine/list.h"
+#include "wine/unicode.h"
+
+WINE_DEFAULT_DEBUG_CHANNEL(wineusb);
+
+static void WINAPI driver_unload(DRIVER_OBJECT *driver)
+{
+    libusb_exit(NULL);
+}
+
+NTSTATUS WINAPI DriverEntry(DRIVER_OBJECT *driver, UNICODE_STRING *path)
+{
+    int err;
+
+    TRACE("driver %p, path %s.\n", driver, debugstr_w(path->Buffer));
+
+    if ((err = libusb_init(NULL)))
+    {
+        ERR("Failed to initialize libusb: %s\n", libusb_strerror(err));
+        return STATUS_UNSUCCESSFUL;
+    }
+
+    driver->DriverUnload = driver_unload;
+
+    return STATUS_SUCCESS;
+}
diff --git a/dlls/wineusb.sys/wineusb.sys.spec b/dlls/wineusb.sys/wineusb.sys.spec
new file mode 100644
index 00000000000..76421d7e35b
--- /dev/null
+++ b/dlls/wineusb.sys/wineusb.sys.spec
@@ -0,0 +1 @@
+# nothing to export
diff --git a/loader/wine.inf.in b/loader/wine.inf.in
index d321c4c8268..e1546713db8 100644
--- a/loader/wine.inf.in
+++ b/loader/wine.inf.in
@@ -2614,6 +2614,7 @@ HKLM,%CurrentVersion%\Telephony\Country List\998,"SameAreaRule",,"G"
 12,,tdi.sys,-
 12,,winebus.sys,-
 12,,winehid.sys,-
+12,,wineusb.sys,-
 ; skip .NET fake dlls in Wine Mono package
 11,,aspnet_regiis.exe,-
 11,,ngen.exe,-
@@ -2665,6 +2666,7 @@ HKLM,%CurrentVersion%\Telephony\Country List\998,"SameAreaRule",,"G"
 12,,tdi.sys
 12,,winebus.sys
 12,,winehid.sys
+12,,wineusb.sys
 ; skip .NET fake dlls in Wine Mono package
 11,,aspnet_regiis.exe,-
 11,,ngen.exe,-