diff --git a/configure b/configure
index 4cb23101f4c..42596bbb9c8 100755
--- a/configure
+++ b/configure
@@ -8727,7 +8727,7 @@ ac_compiler_gnu=$ac_cv_c_compiler_gnu
     WINELOADER_LDFLAGS="-Wl,-pie,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist"
 
     wine_can_build_preloader=yes
-    WINEPRELOADER_LDFLAGS="-nostartfiles -nodefaultlibs -e _start -ldylib1.o -Wl,-image_base,0x7d400000,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist"
+    WINEPRELOADER_LDFLAGS="-nostartfiles -nodefaultlibs -e _start -ldylib1.o -Wl,-image_base,0x7d400000,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist,-segaddr,WINE_4GB_RESERVE,0x100000000"
     { $as_echo "$as_me:${as_lineno-$LINENO}: checking whether the compiler supports -Wl,-no_new_main -e _main" >&5
 $as_echo_n "checking whether the compiler supports -Wl,-no_new_main -e _main... " >&6; }
 if ${ac_cv_cflags__Wl__no_new_main__e__main+:} false; then :
diff --git a/configure.ac b/configure.ac
index 0f8b9f6c080..a9003523700 100644
--- a/configure.ac
+++ b/configure.ac
@@ -753,7 +753,7 @@ case $host_os in
     WINELOADER_LDFLAGS="-Wl,-pie,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist"
 
     wine_can_build_preloader=yes
-    WINEPRELOADER_LDFLAGS="-nostartfiles -nodefaultlibs -e _start -ldylib1.o -Wl,-image_base,0x7d400000,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist"
+    WINEPRELOADER_LDFLAGS="-nostartfiles -nodefaultlibs -e _start -ldylib1.o -Wl,-image_base,0x7d400000,-pagezero_size,0x1000,-sectcreate,__TEXT,__info_plist,loader/wine_info.plist,-segaddr,WINE_4GB_RESERVE,0x100000000"
     WINE_TRY_CFLAGS([-Wl,-no_new_main -e _main],
                     [WINEPRELOADER_LDFLAGS="-Wl,-no_new_main $WINEPRELOADER_LDFLAGS"
                      WINE_TRY_CFLAGS([-Wl,-no_new_main -e _main -nostartfiles -nodefaultlibs],,
diff --git a/loader/preloader_mac.c b/loader/preloader_mac.c
index d86675538bb..fc07b7da0ed 100644
--- a/loader/preloader_mac.c
+++ b/loader/preloader_mac.c
@@ -54,6 +54,17 @@
 #include "wine/asm.h"
 #include "main.h"
 
+/* Rosetta on Apple Silicon allocates memory starting at 0x100000000 (the 4GB line)
+ * before the preloader runs, which prevents any nonrelocatable EXEs with that
+ * base address from running.
+ *
+ * This empty linker section forces Rosetta's allocations (currently ~132 MB)
+ * to start at 0x114000000, and they should end below 0x120000000.
+ */
+#if defined(__x86_64__)
+__asm__(".zerofill WINE_4GB_RESERVE,WINE_4GB_RESERVE,___wine_4gb_reserve,0x14000000");
+#endif
+
 #ifndef LC_MAIN
 #define LC_MAIN 0x80000028
 struct entry_point_command
@@ -79,6 +90,7 @@ static struct wine_preload_info preload_info[] =
     { (void *)0x000000010000, 0x00100000 },  /* DOS area */
     { (void *)0x000000110000, 0x67ef0000 },  /* low memory area */
     { (void *)0x00007ff00000, 0x000f0000 },  /* shared user data */
+    { (void *)0x000100000000, 0x14000000 },  /* WINE_4GB_RESERVE section */
     { (void *)0x7ffd00000000, 0x01ff0000 },  /* top-down allocations + virtual heap */
 #endif /* __i386__ */
     { 0, 0 },                            /* PE exe range set with WINEPRELOADRESERVE */
@@ -395,6 +407,10 @@ static int preloader_overlaps_range( const void *start, const void *end )
             struct target_segment_command *seg = (struct target_segment_command*)cmd;
             const void *seg_start = (const void*)(seg->vmaddr + slide);
             const void *seg_end = (const char*)seg_start + seg->vmsize;
+            static const char reserved_segname[] = "WINE_4GB_RESERVE";
+
+            if (!wld_strncmp( seg->segname, reserved_segname, sizeof(reserved_segname)-1 ))
+                continue;
 
             if (end > seg_start && start <= seg_end)
             {