diff --git a/Make.rules.in b/Make.rules.in
index 696614469c7..7e6a09d2e57 100644
--- a/Make.rules.in
+++ b/Make.rules.in
@@ -11,15 +11,14 @@
 
 # First some useful definitions
 
-DEFS         = -D__WINESRC__ $(EXTRADEFS)
-ALLCFLAGS    = $(DEFS) $(EXTRACFLAGS) $(CPPFLAGS) $(CFLAGS) $(MODCFLAGS)
-IDLFLAGS     = $(DEFS) $(EXTRAIDLFLAGS)
-RCFLAGS      = --nostdinc $(PORCFLAGS) $(DEFS)
+ALLCFLAGS    = $(EXTRACFLAGS) $(CPPFLAGS) $(CFLAGS) $(MODCFLAGS)
+IDLFLAGS     = $(EXTRAIDLFLAGS)
+RCFLAGS      = --nostdinc $(PORCFLAGS)
 
 OBJS = $(C_SRCS:.c=.o) $(BISON_SRCS:.y=.tab.o) $(LEX_SRCS:.l=.yy.o) $(OBJC_SRCS:.m=.o) \
        $(RC_SRCS:.rc=.res) $(MC_SRCS:.mc=.res) $(EXTRA_OBJS)
 
-ALLCROSSCFLAGS = $(DEFS) -DWINE_CROSSTEST $(CPPFLAGS) $(CFLAGS)
+ALLCROSSCFLAGS = $(CPPFLAGS) $(CFLAGS)
 
 # Rules for dependencies
 
diff --git a/tools/makedep.c b/tools/makedep.c
index 28f60fd3b7a..4d386137130 100644
--- a/tools/makedep.c
+++ b/tools/makedep.c
@@ -92,6 +92,7 @@ struct strarray
 static const struct strarray empty_strarray;
 
 static struct strarray include_args;
+static struct strarray define_args;
 static struct strarray make_vars;
 static struct strarray cmdline_vars;
 
@@ -1475,9 +1476,10 @@ static struct strarray output_sources(void)
             {
                 output( "%s.res: $(WRC) $(ALL_MO_FILES) %s\n", obj, sourcedep );
                 output( "\t$(WRC) -o $@ %s", source->filename );
-                output_filenames( includes );
                 if (is_win16) output_filename( "-m16" );
                 else output_filenames( targetflags );
+                output_filenames( includes );
+                output_filenames( define_args );
                 output_filename( "$(RCFLAGS)" );
                 output( "\n" );
                 output( "%s.res rsrc.pot:", obj );
@@ -1487,9 +1489,10 @@ static struct strarray output_sources(void)
             {
                 output( "%s.res: $(WRC) %s\n", obj, sourcedep );
                 output( "\t$(WRC) -o $@ %s", source->filename );
-                output_filenames( includes );
                 if (is_win16) output_filename( "-m16" );
                 else output_filenames( targetflags );
+                output_filenames( includes );
+                output_filenames( define_args );
                 output_filename( "$(RCFLAGS)" );
                 output( "\n" );
                 output( "%s.res:", obj );
@@ -1524,8 +1527,9 @@ static struct strarray output_sources(void)
             output_filenames( targets );
             output( ": $(WIDL)\n" );
             output( "\t$(WIDL) -o $@ %s", source->filename );
-            output_filenames( includes );
             output_filenames( targetflags );
+            output_filenames( includes );
+            output_filenames( define_args );
             output_filename( "$(IDLFLAGS)" );
             output( "\n" );
             output_filenames( targets );
@@ -1602,6 +1606,7 @@ static struct strarray output_sources(void)
             output( "%s.o: %s\n", obj, sourcedep );
             output( "\t$(CC) -c -o $@ %s", source->filename );
             output_filenames( includes );
+            output_filenames( define_args );
             if (module || staticlib || testdll) output_filenames( dllflags );
             output_filename( "$(ALLCFLAGS)" );
             output( "\n" );
@@ -1611,6 +1616,8 @@ static struct strarray output_sources(void)
                 output( "%s.cross.o: %s\n", obj, sourcedep );
                 output( "\t$(CROSSCC) -c -o $@ %s", source->filename );
                 output_filenames( includes );
+                output_filenames( define_args );
+                output_filename( "-DWINE_CROSSTEST" );
                 output_filename( "$(ALLCROSSCFLAGS)" );
                 output( "\n" );
             }
@@ -1642,9 +1649,10 @@ static struct strarray output_sources(void)
         output_filenames( po_files );
         output( "\n" );
         output( "\t$(WRC) -O pot -o $@" );
-        output_filenames( includes );
         if (is_win16) output_filename( "-m16" );
         else output_filenames( targetflags );
+        output_filenames( includes );
+        output_filenames( define_args );
         output_filename( "$(RCFLAGS)" );
         output_filenames( po_files );
         output( "\n" );
@@ -2090,10 +2098,16 @@ static void update_makefile( const char *path )
     parent_dir  = get_expanded_make_variable( "PARENTSRC" );
 
     include_args = empty_strarray;
+    define_args = empty_strarray;
+    strarray_add( &define_args, "-D__WINESRC__" );
+
     value = get_expanded_make_var_array( "EXTRAINCL" );
     for (i = 0; i < value.count; i++)
         if (!strncmp( value.str[i], "-I", 2 ))
             strarray_add_uniq( &include_args, value.str[i] );
+        else
+            strarray_add_uniq( &define_args, value.str[i] );
+    strarray_addall( &define_args, get_expanded_make_var_array( "EXTRADEFS" ));
 
     init_paths();