diff --git a/dlls/wow64/Makefile.in b/dlls/wow64/Makefile.in
index 693fdefaae4..f56d1f0aad9 100644
--- a/dlls/wow64/Makefile.in
+++ b/dlls/wow64/Makefile.in
@@ -5,6 +5,7 @@ IMPORTS   = ntdll winecrt0
 EXTRADLLFLAGS = -nodefaultlibs -mno-cygwin -Wl,--image-base,0x6f000000
 
 C_SRCS = \
+	file.c \
 	registry.c \
 	sync.c \
 	syscall.c \
diff --git a/dlls/wow64/file.c b/dlls/wow64/file.c
new file mode 100644
index 00000000000..361aa1905ee
--- /dev/null
+++ b/dlls/wow64/file.c
@@ -0,0 +1,100 @@
+/*
+ * WoW64 file functions
+ *
+ * Copyright 2021 Alexandre Julliard
+ *
+ * This library is free software; you can redistribute it and/or
+ * modify it under the terms of the GNU Lesser General Public
+ * License as published by the Free Software Foundation; either
+ * version 2.1 of the License, or (at your option) any later version.
+ *
+ * This library is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
+ * Lesser General Public License for more details.
+ *
+ * You should have received a copy of the GNU Lesser General Public
+ * License along with this library; if not, write to the Free Software
+ * Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA 02110-1301, USA
+ */
+
+#include <stdarg.h>
+
+#include "ntstatus.h"
+#define WIN32_NO_STATUS
+#include "windef.h"
+#include "winbase.h"
+#include "winnt.h"
+#include "winternl.h"
+#include "wow64_private.h"
+
+
+/**********************************************************************
+ *           wow64_NtCreateFile
+ */
+NTSTATUS WINAPI wow64_NtCreateFile( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    IO_STATUS_BLOCK32 *io32 = get_ptr( &args );
+    LARGE_INTEGER *alloc_size = get_ptr( &args );
+    ULONG attributes = get_ulong( &args );
+    ULONG sharing = get_ulong( &args );
+    ULONG disposition = get_ulong( &args );
+    ULONG options = get_ulong( &args );
+    void *ea_buffer = get_ptr( &args );
+    ULONG ea_length = get_ulong( &args );
+
+    struct object_attr64 attr;
+    IO_STATUS_BLOCK io;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtCreateFile( &handle, access, objattr_32to64( &attr, attr32 ),
+                           iosb_32to64( &io, io32 ), alloc_size, attributes,
+                           sharing, disposition, options, ea_buffer, ea_length );
+    put_handle( handle_ptr, handle );
+    put_iosb( io32, &io );
+    return status;
+}
+
+
+/**********************************************************************
+ *           wow64_NtDeleteFile
+ */
+NTSTATUS WINAPI wow64_NtDeleteFile( UINT *args )
+{
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+
+    struct object_attr64 attr;
+
+    return NtDeleteFile( objattr_32to64( &attr, attr32 ));
+}
+
+
+/**********************************************************************
+ *           wow64_NtOpenFile
+ */
+NTSTATUS WINAPI wow64_NtOpenFile( UINT *args )
+{
+    ULONG *handle_ptr = get_ptr( &args );
+    ACCESS_MASK access = get_ulong( &args );
+    OBJECT_ATTRIBUTES32 *attr32 = get_ptr( &args );
+    IO_STATUS_BLOCK32 *io32 = get_ptr( &args );
+    ULONG sharing = get_ulong( &args );
+    ULONG options = get_ulong( &args );
+
+    struct object_attr64 attr;
+    IO_STATUS_BLOCK io;
+    HANDLE handle = 0;
+    NTSTATUS status;
+
+    *handle_ptr = 0;
+    status = NtOpenFile( &handle, access, objattr_32to64( &attr, attr32 ),
+                         iosb_32to64( &io, io32 ), sharing, options );
+    put_handle( handle_ptr, handle );
+    put_iosb( io32, &io );
+    return status;
+}
diff --git a/dlls/wow64/struct32.h b/dlls/wow64/struct32.h
index 069564948d0..76055115b08 100644
--- a/dlls/wow64/struct32.h
+++ b/dlls/wow64/struct32.h
@@ -31,6 +31,16 @@ typedef struct
     ULONG SecurityQualityOfService;
 } OBJECT_ATTRIBUTES32;
 
+typedef struct
+{
+    union
+    {
+        NTSTATUS Status;
+        ULONG Pointer;
+    };
+    ULONG Information;
+} IO_STATUS_BLOCK32;
+
 typedef struct
 {
     UNICODE_STRING32 Name;
diff --git a/dlls/wow64/syscall.h b/dlls/wow64/syscall.h
index ab25bcb501d..2b542658f9e 100644
--- a/dlls/wow64/syscall.h
+++ b/dlls/wow64/syscall.h
@@ -38,6 +38,7 @@
     SYSCALL_ENTRY( NtCreateDebugObject ) \
     SYSCALL_ENTRY( NtCreateDirectoryObject ) \
     SYSCALL_ENTRY( NtCreateEvent ) \
+    SYSCALL_ENTRY( NtCreateFile ) \
     SYSCALL_ENTRY( NtCreateIoCompletion ) \
     SYSCALL_ENTRY( NtCreateJobObject ) \
     SYSCALL_ENTRY( NtCreateKey ) \
@@ -53,6 +54,7 @@
     SYSCALL_ENTRY( NtDebugContinue ) \
     SYSCALL_ENTRY( NtDelayExecution ) \
     SYSCALL_ENTRY( NtDeleteAtom ) \
+    SYSCALL_ENTRY( NtDeleteFile ) \
     SYSCALL_ENTRY( NtDeleteKey ) \
     SYSCALL_ENTRY( NtDeleteValueKey ) \
     SYSCALL_ENTRY( NtDuplicateObject ) \
@@ -73,6 +75,7 @@
     SYSCALL_ENTRY( NtMapViewOfSection ) \
     SYSCALL_ENTRY( NtOpenDirectoryObject ) \
     SYSCALL_ENTRY( NtOpenEvent ) \
+    SYSCALL_ENTRY( NtOpenFile ) \
     SYSCALL_ENTRY( NtOpenIoCompletion ) \
     SYSCALL_ENTRY( NtOpenJobObject ) \
     SYSCALL_ENTRY( NtOpenKey ) \
diff --git a/dlls/wow64/wow64_private.h b/dlls/wow64/wow64_private.h
index e9935303cbb..303914c540e 100644
--- a/dlls/wow64/wow64_private.h
+++ b/dlls/wow64/wow64_private.h
@@ -105,6 +105,13 @@ static inline void *apc_param_32to64( ULONG func, ULONG context )
     return (void *)(ULONG_PTR)(((ULONG64)func << 32) | context);
 }
 
+static inline IO_STATUS_BLOCK *iosb_32to64( IO_STATUS_BLOCK *io, IO_STATUS_BLOCK32 *io32 )
+{
+    if (!io32) return NULL;
+    io->Pointer = io32;
+    return io;
+}
+
 static inline UNICODE_STRING *unicode_str_32to64( UNICODE_STRING *str, const UNICODE_STRING32 *str32 )
 {
     if (!str32) return NULL;
@@ -178,6 +185,17 @@ static inline void put_size( ULONG *size32, SIZE_T size )
     if (size32) *size32 = min( size, MAXDWORD );
 }
 
+static inline void put_iosb( IO_STATUS_BLOCK32 *io32, const IO_STATUS_BLOCK *io )
+{
+    /* sync I/O modifies the 64-bit iosb right away, so in that case we update the 32-bit one */
+    /* async I/O leaves the 64-bit one untouched and updates the 32-bit one directly later on */
+    if (io32 && io->Pointer != io32)
+    {
+        io32->Status = io->Status;
+        io32->Information = io->Information;
+    }
+}
+
 extern void put_section_image_info( SECTION_IMAGE_INFORMATION32 *info32,
                                     const SECTION_IMAGE_INFORMATION *info ) DECLSPEC_HIDDEN;